A Milk-Free Diet Down Regulates Folate Receptor Autoimmunity in Cerebral Folate Deficiency Syndrome, as printed on NIH Public Access, July 2009

In cerebral folate deficiency syndrome, the presence of autoantibodies against the folate receptor (FR) explains decreased folate transport to the central nervous system and the clinical response to folinic acid.  Autoantibody cross reactivity with milk FR from different species prompted us to test the effect of a milk-free diet. 

Our Journey Through Autism and Cerebral Folate Deficiency, as printed in Autism Science Digest, July 2012

This article is a companion piece to Dr. Richard Frye's article on cerebral folate deficiency (CFD).  The article details the family struggles to get a proper diagnosis for Evan Carkhuff, whom many professionals perceived as having separate, non-connected disorders.  The article also discusses the hope the Carkhuffs now have after beginning treatment for CFD with Dr. Frye and finding answers to questions about the medical basis for Evan's condition. 

Cerebral Folate Deficiency in Autism Spectrum Disorders, as printed in Autism Science Digest, July 2012

This article is about Evan Carkhuff, a child diagnosed with autism who went many years with neither a medical diagnosis nor an explanation for his medical condition.  Here we explain the medical science of the underlying neurodevelopmental disorder with which he was eventually diagnosed, called cerebral folate deficiency (CFD). As you will read from the description of his disorder in the accompanying article, Evan had several atypical characteristics that led some physicians down a wrong path.  Evan's story is an excellent example of a disorder that was previously thought to be rare but is now being increasingly recognized to affect some children with autism. 

Arkansas Children's Hospital Research Success Update  

Observation is often the inspiration to explore a medical problem. While at the University of Texas Health Science Center at Houston, Dr. Richard Frye, now ACHRI’s Director of Autism Research, noticed autistic patients with cerebral folate deficiency (CFD) had improvements when treated with folinic acid. A three-year-old named Evan was among the first patients with CFD and autism that Dr. Frye diagnosed and treated. “His significant response was one the reasons I pursued diagnosis and treatment of this condition in other children,” says Dr. Frye.



Autism affects 1 in 68 children.

Email for more information to info@cfdresearch.org